There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

Introduction In vivo imaging provides a window into the spatially complex, rapidly evolving
physiology of the cell that structural imaging alone cannot. However, observing this …

IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs
targeting either cytokine are highly effective treatments for this disease. The efficacy of …

One of the great challenges in science and engineering today is to develop technologies to
improve the health of people in the poorest regions of the world. Here we integrated new …

Single-cell transcriptomic analysis is widely used to study human tumors. However, it remains
challenging to distinguish normal cell types in the tumor microenvironment from malignant …

Human neonates infected with herpes simplex virus 1 (HSV-1) develop one of three distinct
patterns of infection: (i) infection limited to the skin, eye or mouth; (ii) infection of the CNS; or (…

Background Few options for transplantation currently exist for patients highly sensitized to
HLA. This exploratory, open-label, phase 1–2, single-center study examined whether …

Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …

Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which
is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of …

We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to
support development of engineered lung tissue from murine embryonic stem cells (mESCs). …