Over the last half century, film coating technology has evolved significantly in terms of
compositions and manufacturing processes, allowing for greater functionality, flexibility and …

Amorphous engineered particle compositions of itraconazole (ITZ) and potential concentration
enhancing polymers, cellulose acetate phthalate (CAP) and polyvinyl acetate phthalate (…

Many techniques for the production of solid dispersions rely on elevated temperatures and
prolonged material residence times, which can result in decomposition of temperature-…

Previous attempts to improve the dissolution and absorption properties of itraconazole (ITZ)
through advanced formulation design have focused only on release in acidic media; however…

Purpose To investigate the use of Carbopol® 974P as a stabilizing agent for supersaturated
levels of itraconazole (ITZ) in neutral pH aqueous media and the resultant effects on oral …

Pharmaceutical Extrusion Technology is the only resource to provide in-depth descriptions
and analyses of the key parameters of extruders and extrusion processes. The book …

The development of new pharmaceutical products has successfully addressed a multitude
of disease states; however, new product development for treating disorders of the central …

Thermal manufacturing methods for the production of solid dispersions frequently require the
addition of a plasticizer in order to achieve requisite molten material flow properties when …

In this study, hot melt extrusion (HME) and KinetiSol® Dispersing (KSD) were utilized to prepare
dissolution-enhanced solid dispersions of Roche Research Compound A (ROA), a BCS …

Objectives: To investigate the ability of KinetiSol® Dispersing to prepare amorphous solid
dispersions of itraconazole using concentration-enhancing polymers. Methods: Concentration-…