A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the β-amyloid
protein (Aβ) in specific brain regions. Both the generation and clearance of Aβ are …

… D 92 TG and D 298 SG are the active site aspartic acid motifs and together they compose
the catalytic domain of BACE1. SP, Pro, TM, and C represent signal peptide, propeptide, …

Despite considerable advances in the past decade, melanin research still suffers from the
lack of universally accepted and shared nomenclature, methodologies, and structural models. …

Alzheimer’s disease is the most common form of dementia, characterized by two pathological
hallmarks: amyloid-β plaques and neurofibrillary tangles 1 . The amyloid hypothesis of …

Mutations in two recently identified genes appear to cause the majority of early–onset familial
Alzheimer's disease (FAD). These two novel genes, presenilin 1 (PS1) and presenilin 2 (…

… where DL(Q) ∈ R(2L+1)×(2L+1) is a Wigner D-matrix of order L. A feature labelled with L = 0
… [Yes] (d) Have you read the ethics review guidelines and ensured that your paper conforms …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

… d, Western blot showing a decrease in both α- and β-APP-CTF levels after 4 d of treatment
with the ACAT inhibitor CP113,818 (10 μM). APP-CTFs were detected as described for Fig. 2. …

… tagged PR20 (Figures 4D and 4E), and found in full-droplet bleaching experiments that
demixed PR readily interchanges with PR in the dispersed phase (Figure 4D). Bleaching within …

… Samples were dissolved at 1 mm concentration in H 2 O:D 2 O (9:1, v/v) and centrifuged
prior to use. The spectra were recorded at 25C. For CD spectroscopy, ERD10 and ERD14 were …