The formation of Ca 2+ microdomains during T cell activation is initiated by the production of
nicotinic acid adenine dinucleotide phosphate (NAADP) from its reduced form NAADPH. …

Toll-like receptors discriminate between different pathogen-associated molecules and activate
signaling cascades that lead to immune responses. The specificity of Toll-like receptor …

We have evaluated the role played by BRCA1 in mediating the phenotypic response to a
range of chemotherapeutic agents commonly used in cancer treatment. Here we provide …

Bronchitis, asthma, and cystic fibrosis, marked by inflammation and mucus hypersecretion,
can be caused or exacerbated by airway pathogens or irritants including acrolein, an …

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate
immune system as they detect conserved viral pathogen-associated molecular patterns (…

Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β)
and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a …

A key part of the innate immune system is a network of pattern recognition receptors (PRRs)
and their associated intracellular signalling pathways. Toll-like receptors (TLRs) are one …

Toll-like receptors (TLRs) have a central role in innate immunity as they detect conserved
pathogen-associated molecular patterns (PAMPs) on a range of microbes, including viruses, …

A facile 6-exo-trig cyclization of σ-aromatic radicals has allowed the synthesis of various
aromatic ring fused benzimidazoles and benzimidazolequinones. The most highly conjugated …

We show that DNA replication activity in extracts of human HeLa cells decreases following
UV irradiation. Alterations in replication activity in vitro parallel the UV‐induced block in cell …