[HTML][HTML] A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (C15: 0) and heptadecanoic acid (C17: 0) in health and disease
The role of C17:0 and C15:0 in human health has recently been reinforced following a number
of important biological and nutritional observations. Historically, odd chain saturated fatty …
of important biological and nutritional observations. Historically, odd chain saturated fatty …
[HTML][HTML] Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial
…, JL Donovan, PA Elliott, A French, S Jagdev, B Jenkins… - The Lancet, 2020 - thelancet.com
Background Urothelial carcinomas of the upper urinary tract (UTUCs) are rare, with poorer
stage-for-stage prognosis than urothelial carcinomas of the urinary bladder. No international …
stage-for-stage prognosis than urothelial carcinomas of the urinary bladder. No international …
[HTML][HTML] Results of the c-TRAK TN trial: a clinical trial utilising ctDNA mutation tracking to detect molecular residual disease and trigger intervention in patients with …
NC Turner, C Swift, B Jenkins, L Kilburn, M Coakley… - Annals of …, 2023 - Elsevier
Background Post-treatment detection of circulating tumour DNA (ctDNA) in early-stage triple-negative
breast cancer (TNBC) patients predicts high risk of relapse. c-TRAK TN assessed …
breast cancer (TNBC) patients predicts high risk of relapse. c-TRAK TN assessed …
[HTML][HTML] Health system challenges to integration of mental health delivery in primary care in Kenya-perspectives of primary care health workers
Background Health system weaknesses in Africa are broadly well known, constraining
progress on reducing the burden of both communicable and non-communicable disease (Afr …
progress on reducing the burden of both communicable and non-communicable disease (Afr …
[HTML][HTML] Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
…, J Blagih, F Zani, A Rees, DG Hill, BJ Jenkins… - Nature …, 2021 - nature.com
Fructose intake has increased substantially throughout the developed world and is
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …
associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our …
[HTML][HTML] Odd chain fatty acids; new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance
BJ Jenkins, K Seyssel, S Chiu, PH Pan, SY Lin… - Scientific reports, 2017 - nature.com
Recent findings have shown an inverse association between circulating C15: 0/C17: 0 fatty
acids with disease risk, therefore, their origin needs to be determined to understanding their …
acids with disease risk, therefore, their origin needs to be determined to understanding their …
[PDF][PDF] Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
BJ Jenkins, J Blagih, FM Ponce-Garcia, M Canavan… - Cell Metabolism, 2023 - cell.com
Augmented T cell function leading to host damage in autoimmunity is supported by metabolic
dysregulation, making targeting immunometabolism an attractive therapeutic avenue. …
dysregulation, making targeting immunometabolism an attractive therapeutic avenue. …
Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions
BH Jenkins, JF Buckingham, CJ Hanley… - Pharmacology & …, 2022 - Elsevier
Cancer-associated fibroblasts (CAFs) are a common cell in the tumour microenvironment
with diverse tumour-promoting functions. Their presence in tumours is commonly associated …
with diverse tumour-promoting functions. Their presence in tumours is commonly associated …
Microstructure understanding of high Cr-Ni austenitic steel corrosion in high-temperature steam
The microstructure and microchemistry of the oxide scales formed on Fe-21Cr-32Ni and Fe-17Cr-9Ni
steels after exposure to deaerated high-temperature high-pressure steam at 600 C …
steels after exposure to deaerated high-temperature high-pressure steam at 600 C …
[HTML][HTML] Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells
…, D Rimmington, I Cimino, DA Goldspink, B Jenkins… - Scientific Reports, 2021 - nature.com
Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body
weight, the mechanisms of action are still elusive. Recent studies have identified the …
weight, the mechanisms of action are still elusive. Recent studies have identified the …