OBJECTIVE: In the recent years liver segmentation from computed tomography scans has
gained a lot of importance in the field of medical image processing since it is the first and …

Chromosomes have a complex architecture in the cell nucleus, which serves vital functional
purposes, yet its structure and folding mechanisms remain still incompletely understood. …

The regulatory specificity of enhancers and their interaction with gene promoters is thought
to be controlled by their sequence and the binding of transcription factors. By studying Pitx1, …

Titanium alloys, especially β-type alloys containing β-stabilizing elements, constitute a highly
versatile category of metallic materials that have been under constant development for …

Long-range gene regulation involves physical proximity between enhancers and promoters
to generate precise patterns of gene expression in space and time. However, in some cases, …

The spatial organization of chromosomes has key functional roles, yet how chromosomes
fold remains poorly understood at the single-molecule level. Here, we employ models of …

Regulatory landscapes drive complex developmental gene expression, but it remains unclear
how their integrity is maintained when incorporating novel genes and functions during …

Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each other …

The inability of the avascular region of the meniscus to regenerate has led to the use of tissue
engineering to treat meniscal injuries. The aim of this study was to evaluate the ability of …

Cancer is one of the most frequently diagnosed diseases, and despite the continuous efforts
in searching for new and more effective treatments, its morbidity and mortality remain a …